Axumin is available as a solution for injection, which is given as a single injection into a vein around 3 to 5 minutes before the patient is to undergo a PET scan. Axumin PET is a procedure for men with supsected prostate cancer recurrence based on high PSA levels. Axumin is a sterile, non-pyrogenic, clear, colorless, hyperosmolal (approximately 500 mOsm/kg to 540 mOsm/kg) injection for intravenous use. Axumin ® (fluciclovine F 18) injection is indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment. Axumin (Fluciclovine F-18) PET Scanning For Prostate Cancer Care. Axumin scan results lead to a change from the pre-scan proposed treatment plan in a majority of cases. Each milliliter contains up to 2 micrograms of fluciclovine, 335 MBq to 8,200 MBq (9 mCi to 221 mCi) fluciclovine F 18 at calibration time and date, and 20 mg trisodium citrate in water for injection. A PET scan can help doctors test for disease, prepare for surgery, and see how well treatments are working. You might get one for several reasons, but they're most often used with cancer, heart disease, and brain conditions. Your doctor may use a PET scan to: The study is usually done if levels of prostate-specific antigen (PSA) rise after treatment. The bone scan did not reveal any suspicious bony metastasis. PET use in prostate cancer widens, but questions remain. Positron Emission Tomography (PET) for Other Specific Indications PET for other specific conditions may be covered wh en criteria are met. Within that population, one-third will develop metastases within 8 years. Typically, detection of prostate cancer recurrence has relied upon PSA (prostate-specific antigen) levels and limited information that can be provided by MRI and ultrasound examinations. Gallium-68 PSMA vs. fluorine-18 fluciclovine PET/CT scans. Axumin is an FDA-approved agent used for Axumin PET scans for prostate cancer. Locations can be viewed at the Axumin Imaging Center Location Directory www.Axumin.com [control+click link to follow]. Imaging will be performed utilizing F-18 fluciclovine, known as Axumin. • Instruct patients not to eat or drink for at least 4 hours before the PET scan (other than small amounts of water for taking medications). In this interview, Mark Frydenberg, MD, discusses the evolution of PET scanning, its clinical indications, its advantages and drawbacks, and key questions that remain about its use. Axumin (fluciclovine F18) Imaging Center Directory. The scan … It is done for patients who have still have symptoms of cancer after being treated for the disease. Refer to the following National Coverage Determinations (NCDs): NCD for PET for Perfusion of the Heart (220.6.1). Axumin ® (fluciclovine F 18) injection is indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment. Why? Currently, in the United States and many other countries, most men diagnosed with high-risk localized prostate cancer undergo additional testing to see if there is evidence of metastatic canc… Aetna considers PET scans experimental and investigational for Alzheimer's disease (including the use of florbetapir-PET and flutemetamol F18-PET for imaging beta-amyloid), dementia, Huntington disease, Parkinson's disease, or for other neurologic indications not listed as medically necessary in this policy because of insufficient evidence of its effectiveness. The Axumin scan showed this not to be the case. AXUMIN PET/CT Protocol Radiology Department September 2018 Rev 01 1 . still useful for patients on androgen suppression therapy? Image interpretation errors can occur with Axumin PET imaging. IMPORTANT SAFETY INFORMATION. According to a presentation given yesterday at the ASCO meeting here in Chicago, PET/CT scanning with 68 Ga-PSMA-11 is more accurate than 18 F-fluciclovine PET/CT at detecting recurrent prostate cancer in men with early biochemical recurrence following radical prostatectomy. RADIOLOGY ASSOCIATES OF OCALA, P.A. Limitations of current imaging procedures include… A metastasis shows that the cancer has the biologic capacity to spread around the bodya process that ultimately leads to death in more than half of prostate cancer patients. PSA can also be elevated due to growing cancer that has metastasized to the lymph nodes or bones. One interesting side note is that after the Axumin scan my PSA dropped to 0.05 from 1.60 and has stayed there for one year, now. If you're a healthcare provider and are not able to find a local imaging site, or have other questions about a specific imaging center, please contact Siemens Healthineers' PETNET Solutions Customer Care at 877-473-8638. (PET) in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen IMPORTANT SAFETY INFORMATION • Image interpretation errors can occur with Axumin PET imaging. The tracer collects in areas of your body that have high… On MDsave, the cost of an Axumin Drug for PET Scan (add-on) is $4,220. Combining these scans creates a more complete image than either test can offer alone. The tracer may be injected, swallowed or inhaled, depending on which organ or tissue is being studied. Evaluation of ischemic heart disease. It showed a positive hit of a lesion less than 1 cm in the right internal obturator lymph node. This removes the requirement for prospective data collection by the National Oncologic PET … Answer from: Radiation Oncologist at Community Practice. (Accessed November 10, 2020) A whole-body PET scan can detect differences in body functions , such as blood flow, use of oxygen, and uptake of sugar (glucose) molecules . This allows your doctor to see how certain organs are functioning. IMPORTANT SAFETY INFORMATION. TRICARE covers PET scans for the following: Diagnosis and management of seizure disorders. A positron emission tomography (PET) scan is an imaging test that helps reveal how your tissues and organs are functioning. Are prostate PET scans (axumin, PSMA, etc.) Up to one-third of menthat have had treatment for primary prostate cancer experience a biochemical recurrence within 10 years. A PET scan uses a radioactive drug (tracer) to show this activity. PO Box 6200 Ocala, Florida 34478-6200 Scheduling: (352) 671-4300 - Fax: (352) 732-8010 See details on each imaging … • … This relies on the Warburg effect, the notion that cancer cells consume glucose at a higher rate than other cells. This study is used to diagnose cancer in the prostate gland. the PSA is mildly increased. A CT scan provides detailed pictures of tissues and organs inside the body, while a PET scan reveals any abnormal activity. Axumin ® (fluciclovine F 18) injection is indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment. Axumin® fl( ucicol vnie F 18) injection is indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment. Staging and restaging of differentiated (follicular, papillary, Hurthle cell) thyroid cancer. This scan can sometimes detect disease before it shows up on other imaging tests. 18F-fluciclovine PET/CT is performed significantly differently from 18F-FDG PET/CT and requires special attention to patient preparation, injection technique, and imaging time. Fluciclovine scan (also known as an “Axumin PET/CT exam”) is a nuclear medicine study using positron emission tomography (PET) with computed tomography (CT) to localize recurrent disease in patients who were previously treated for prostate cancer and now … The PET/CT AXUMIN studies are performed strictly for recurrent Prostate Cancer imaging. Fluciclovine (18F), also known as anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid (FACBC), or as Axumin (brand name), and colloquially as anti-3 [18F] FACBC or F18, is a diagnostic agent "indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated prostate specific antigen (PSA) levels." There was no positive reaction in the fossa. Systemic recurrences are tremendously more dangerous than local recurrences. Axumin PET showed mild activity (SUVmax 1.5) in the prostate bed, but not significantly higher than the blood pool activity (SUVmax 1.4), thus not suspicious for recurrence at the prostatic bed per the guideline. This is called a systemic recurrence. Thus, knowing the location of th… A study at Emory University, Schreibmann et al, Int J Radiation Oncol Biol Phys , 2016, reported treatment plan changes in 41 patients based on imaging in patients having had both the 18F-Fluciclovine PET/CT and a high-resolution CT. Fluciclovine tagged PET scans appear to be more sensitive than CT scans and to [11C]-tagged choline PET scans. Axumin is often able to image and restage recurrent prostate cancer better than any other conventional imaging techniques. Synthetic amino acid that is labeled with the radioisotope F 18 for PET imaging. Thereafter, the patient was referred to our center for Axumin PET scan. The Axumin PET/CT scan is available at over 400 locations throughout the USA. 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